There was also a moment of magic from the former world number one on the seventh, when he drilled a 172-yard approach shot to five feet and then tapped in for birdie.
He was denied a bigger lead after bogeys on the ninth and 16th holes.
“I got off to a nice start and made some nice putts. Good Lord,” Woods said afterwards.
“I left myself in good spots, too, so I was able to take a run at some of the putts. Other than number three, every putt was uphill, so it was nice. I felt like I could free-wheel it, and they went in.”
A Woods victory would be an 80th PGA Tour triumph and take him to within two wins of Sam Snead’s all-time 82 Tour victories.
“I would love to be able to win this event,” he said.
“I’ve got a three-shot lead. I’ve got a bunch of guys behind me that have been playing well and are playing well, and we’ll see what happens tomorrow.”
With one round remaining, Woods leads by three from Rory McIlroy and Justin Rose on nine under.
“Simple math says that if I play a clean card, the guys behind me have to shoot 67 to force it into extra,” Woods added.
“So, that helps. I don’t have to shoot 63 or 64 and hope I get help. That’s a big difference.
“This is a spot I’d much rather be in than certainly four or five back.”
And having won 106 tournaments around the globe, Woods was quizzed if there was any further room for a 107th victory prize.
“I am sure there would be room somewhere in the house if I happened to go on and win this event,” he said.
Woods’ last victory came 1,875 days ago in August 2013 when he captured the WGC-Bridgestone Invitational.
The 14-time Major winner is a two-time former Tour Championship winner and enjoys a remarkable record of winning 54 of 57 PGA Tour events when holding the 54-hole lead.
The 42-year-old returned to golf this season after missing most of the previous two years with a debilitating back injury.
However Woods has progressed steadily during his comeback season, leading the British Open during the final round in July before finishing second at last month’s PGA Championship.
He fired a 62 earlier this month and has also done enough to force himself into the USA team for next week’s Ryder Cup.
Behind Woods, McIlroy is lurking menacingly after carding a four-under-par 66.
Overnight leader Rose remains in the hunt but will look to improve on Sunday after a two-under-par 68.
Kyle Stanley and Spain’s Jon Rahm are a further three shots back on six under, six strokes behind Woods.
Paul Casey, Tony Finau and Billy Horschel are seven off the lead on five under.
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